Accelerating Breakthrough Discoveries into Medicines

Jonathan Stamler

Jonathan Stamler, MD


Jonathan S. Stamler, MD, President, Harrington Discovery Institute, is an internationally renowned physician-scientist, recognized for the discovery of protein S-nitrosylation, a fundamental mechanism for controlling protein function that operates across phylogeny and in all cell types and tissues. Dysregulated S-nitrosylation is commonly associated with disease ranging form heart disorders to neurological syndromes and cancer.

Dr. Stamler’s elucidation of the cellular mechanisms of action of S-nitrosylation has provided new insights into multiple aspects of mammalian physiology, including the regulation of cardiac, skeletal muscle, and airway contractility, as well as the discovery of red blood cell-mediated vasodilation. That discovery revealed the critical role in the respiratory cycle played by hemoglobin-derived and nitric oxide-based vasoactivity, thereby redefining the respiratory cycle as a 3-gas system: O2/NO/CO2.

His laboratory is known for additional groundbreaking work on hemoglobins in mammals, invertebrates and microbes, including the discovery of novel enzymatic functions of hemoglobins that provide protection against nitric oxide in lower organisms. He also identified the molecular mechanism of nitroglycerin bioactivation and tolerance.

Dr. Stamler is a graduate of Brandeis University and received his medical degree from Mount Sinai School of Medicine. He completed his internship, residency and fellowships in cardiovascular and pulmonary medicine at Harvard Medical School and Brigham and Women’s Hospital. He was a member of the faculty at Harvard University before spending sixteen years at Duke University and the Howard Hughes Medical Institute.

In 2010, Dr. Stamler relocated to Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, where he holds the Robert S. and Sylvia K. Reitman Family Foundation Distinguished Chair of Cardiovascular Innovation, is a Professor of Medicine and of Biochemistry, and serves as Director of the Institute for Transformative Molecular Medicine as well as President of the Harrington Discovery Institute, which he co-founded.

Dr. Stamler has published more than 300 original scientific papers and chapters and edited two books. He has co-founded seven biotechnology companies and licensed two additional programs to major pharmaceutical companies, and he holds more than 125 patents and patent applications. He has received numerous awards and prizes, including recognition by the Ewing Marion Kauffman Foundation for being among the “Top Innovators in America” and by the American Heart Association as a “Distinguished Scientist.”